Rhubarb Anthraquinones Protect Rats against Mercuric Chloride (HgCl2)-Induced Acute Renal Failure
نویسندگان
چکیده
منابع مشابه
Rhubarb Anthraquinones Protect Rats against Mercuric Chloride (HgCl₂)-Induced Acute Renal Failure.
Mercury (Hg) causes severe nephrotoxicity in subjects with excess exposure. This work attempted to identify whether a natural medicine--rhubarb--has protective effects against mercuric chloride (HgCl₂)-induced acute renal failure (ARF), and which of its components contributed most to the treatment. Total rhubarb extract (TR) were separated to the total anthraquinones (TA), the total tannins (TT...
متن کاملMelatonin attenuates acute renal failure and oxidative stress induced by mercuric chloride in rats.
We evaluated the effect of melatonin (Mel), a potent scavenger of reactive oxygen species, in the course of HgCl(2)-induced acute renal failure. Rats received by gastric gavage 1 mg/kg of Mel (n = 21) or vehicle (n = 21), 30 min before the subcutaneous injection of HgCl(2) (2.5 mg/kg). Rats were killed at 24, 48, and 72 h, and plasma creatinine (S(cr)), renal histology, proliferative activity, ...
متن کاملFailure of chronic sodium chloride loading to protect against norepinephrine-induced acute renal failure in dogs.
We previously have shown that chronic sodium chloride (NaCl) loading protects against HgCl2-induced acute renal failure (ARF) in dogs. To determine whether NaCl loading protects against an ischemic model of ARF, unilateral oliguric renal failure was produced by the infusion of norepinephrine (NE) into the renal artery of both saline-expanded (SE) and water-drinking (WD) dogs (n = 7). The renal...
متن کاملProtective Effects of Crocin against Cisplatin-Induced Acute Renal Failure and Oxidative Stress in Rats
Background. The major side effect of cisplatin, used in some tumours, is nephrotoxicity. Reactive oxygen species and oxidative damage are the most important factors in cisplatin-induced acute renal failure. The main purpose of this study is to investigate the protective effects of crocin against cisplatin-induced acute renal failure and oxidative stress in rat. Methods. In this study, animal...
متن کاملN-acetylcysteine and deferoxamine protect against acute renal failure induced by ischemia/ reperfusion in rats
Renal ischemia is observed in a variety of clinical situations, such as cardiac arrest with recovery, liver and kidney transplantation and partial nephrectomy. The acute renal failure (ARF) observed after ischemia is characterized by a decreased glomerular filtration rate, tubular necrosis and increased renal vascular resistance.(1,2) The ischemia/reperfusion process (I/R) involves multiple pat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecules
سال: 2016
ISSN: 1420-3049
DOI: 10.3390/molecules21030298